Selected Publications

Shen Q, Xu C, Jang, S, Xiong Q, Devarkar SC, Tian T, Bedwell GJ, Tripler TN, Hu Y, Yuan S, Temple, J, Shi J, Aiken C, Engelman AN, Perilla JR, Lusk CP, Lin C, Xiong Y. (2020). A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid. bioRxiv doi:

Yuan S, Peng L, Park JJ, Hu Y, Devarkar SC, Dong MB, Wu S, Chen S, Lomakin I, Xiong Y. (2020). Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA. bioRxiv doi:

Hu Y, Desimmie BA, Nguyen HC, Ziegler SZ, Cheng TC, Chen J, Wang J, Wang H, Zhang K, Pathak VK, & Xiong Y. (2019). Structural basis of antagonization of human APOBEC3F by HIV-1 Vif. Nat. Struct. Mol. Biol. 26, 1176–1183.

Summers BJ, Digianantonio KM, Smaga SS, Huang P, Zhou K, Gerber EE, Wang W& Xiong Y. (2019). Modular HIV-1 Capsid Assemblies for Investigating Diverse Host-Capsid Recognition Mechanisms. Cell Host & Microbe 26, 216.

Huang P, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH & Xiong Y. (2019). FEZ1 is recruited to a conserved cofactor site on capsid to promote HIV-1 trafficking. Cell Reports 28, 2373-2385. Epub Aug. 14, 2019.

Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl Jr. J, Keppler OT, Xiong Y (2018). The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. USA. doi:10.1073/pnas.1805593115

Jia X, Zhao Q & Xiong Y (2015). HIV Suppression by Host Restriction Factors and Viral Immune Evasion. Curr. Opin. Struct. Biol. 31:106-14.

Fribourgh J, Nguyen H, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A & Xiong Y (2014). Structural Insight into HIV-1 Restriction by Myxovirus Resistance Protein 2 (MxB). Cell Host Microbe 16, 627-638. Epub Oct 9, 2014.

Ji X, Tang C, Zhao Q, Wang W & Xiong Y (2014). Structural basis of Cellular dNTP regulation by SAMHD1. Proc. Natl. Acad. Sci. USA. 111, E4305-E4314. Epub Sep 29, 2014.

Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J & Xiong Y (2014). Structural Basis of HIV-1 Vpu-Mediated BST2 Antagonism via Hijacking of the Clathrin Adaptor Protein Complex 1. eLife 3: e02362.

Ji X, Wu Y, Yan J, Mehrens J, Yang H, DeLucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J & Xiong Y (2013). Mechanism of Allosteric Activation of SAMHD1 by dGTP. Nat. Struct. Mol. Biol. 20, 1304-1309. Epub 2013 Oct 20.

Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P & Xiong Y (2012). Structural Insight into HIV-1 Capsid Recognition by Rhesus TRIM5α. Proc. Natl. Acad. Sci. USA. 109,18372-18377.

Jia X, Sing R, Homann S, Yang H, Guatelli J & Xiong Y (2012). Structural Basis of Evasion of Cellular Adaptive Immunity by HIV-1 Nef. Nat. Struct. Mol. Biol. 19, 701-706.