Publication List

2023

130. Hu Y, Delviks-Frankenberry KA, Wu C, Arizaga F, Pathak VK & Xiong Y. Structural Insights into PPP2R5A Degradation by HIV-1 Vif. Nat Struct Mol Biol (in press).

129. Lyu W, Duan D, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske AJ (2023). Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation. Current Biology 21, 4582-4598.

128. Maehigashi T, Lim C, Wade LR, Bowen NE, Knecht KM, Alvarez NN, Kelly WG, Schinazi RF, Kim DH, Xiong Y, Kim B. (2023) Biochemical functions and structure of Caenorhabditis elegans ZK177. 8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog. J. Biol. Chem. 299,105148.

127. Devarkar SC, Vetick M, Balaji S, Lomakin IB, Yang L, Jin D, Gilbert W, Chen S, Xiong Y. (2023). Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses. Cell Reports 42, 113156.

126. Ren P, Hu Y, Peng L, Yang L, Suzuki K, Fang Z, Bai M, Zhou L, Feng Y, Zou Y, Xiong Y*, Chen S*. (2023). Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages. Sig Transduct Target Ther 8, 281. *Corresponding authors.

125. Espada CE, Levent S, Cahill MP, Phillips S, Martinez N, Lin M, Xiong Y, Wu L. (2023). SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection. J. Biol. Chem. 299,104925.

124. Yang H, Espada CE, Phillips S, Martinez N, Kenney AD, Yount JS, Xiong Y, Wu L. (2023). The host anti-viral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection. J. Biol. Chem. 299, 104750.

123. Wu C, Xiong Y. (2023). Enrich and switch: IP6 and maturation of HIV-1 capsid. Nat Struct Mol Biol 30, 239–241.

122. Shen Q, Kumari S, Xu C, Jang, S, Burdick RC, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Shi J, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y. (2023). The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proc. Natl. Acad. Sci. USA. 120, e2202815120.

121. Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. (2023). Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nat Struct Mol Biol 30, 425–435.

120. Hu Y, Gudnadóttir RB, Knecht KM, Arizaga F, Jónsson SR, Xiong Y. (2023). Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi–visna virus Vif. Sci. Adv. 9, eadd3422. DOI: 10.1126/sciadv.add3422.

2022

119. Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity. Shen Q, Xiong Q, Zhou K, Feng Q, Liu L, Tian T, Wu C, Xiong Y, Melia TJ, Lusk CP, Lin C. (2022). J. Am. Chem. Soc. DOI: 10.1021/jacs.2c11226.

118. Papini C, Wang Z, Kudalkar SN, Schrank TS, Tang S, Sasaki T, Wu C, Tejada B, Ziegler SJ, Xiong Y, Issaeva N, Yarbrough WG, Anderson KS. (2022). iScience 25 (10), 105077.

117. Wang J, Liu J, Gisriel CJ, Wu S, Maschietto F, Flesher DA, Lolis E, Lisi GP, Brudvig GW, Xiong Y, Batista VS. (2022). How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM. J Struct Biol 214, 107902.

116. Han L, Rao Q, Yang R, Wang Y, Chai P, Xiong Y, Zhang K. (2022). Cryo-EM structure of an active central apparatus. Nat Struct Mol Biol 29(5), 472-482.

115. Yoh SM, Mamede J, Lau D, Ahn N, Sanchez MT, Temple J, Tuckwell A, Fuchs NV, Cianci G, Riva L, Curry H, Yin X, Gambut S, Simons LM, Hultquist JF, Koenig R, Xiong Y, Garcia-Sastre A, Böcking T, Hope TJ, Chanda S. (2022). Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA. Molecular Cell 82, 2871-2884

114. Peng L, Hu Y, Mankowski M, Ren P, Chen R, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow R, Fang Z, Wu C, Dong M, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond M, Wilen C*, Xiong Y *, Chen S*. (2022). Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nature Communications 13(1):1638.doi:10.1038/s41467-022-29288-3. PMCID: PMC8960874 * Corresponding authors.

2021

113. Shen Q, Wu C, Freniere C, Tripler TN, Xiong Y. (2021). Nuclear Import of HIV-1. Viruses 13(11):2242. PMCID: PMC8619967.

112. Rothenburger T, Thomas D, Schreiber Y, Wratil PR, Pflantz T, Knecht K, Digianantonio K, Temple J, Schneider C, Baldauf HM, McLaughlin KM, Rothweiler F, Bilen B, Farmand S, Bojkova D, Costa R, Ferreirós N, Geisslinger G, Oellerich T, Xiong Y, Keppler OT, Wass MN, Michaelis M, Cinatl J Jr. (2021). Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells. J Exp Clin Cancer Res. 40(1):317. PMCID: PMC8507139.

111. Bowen NE, Temple J, Shepard C, Oo A, Arizaga F, Kapoor-Vazirani P, Persaud M, Yu CH, Kim DH, Schinazi RF, Ivanov DN, Diaz-Griffero F, Yu DS, Xiong Y, Kim B. (2021). Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J. Biol. Chem. 297(4):101170. PMCID: PMC8497992.

110. Yuan S, Balaji S, Lomakin IB, Xiong Y. (2021). Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition. Front Microbiol. 12:752214. PMCID: PMC8512706.

109. Shen Q, Tian T, Xiong Q, Ellis Fisher PD, Xiong Y, Melia TJ, Lusk CP, Lin C. (2021). DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins. J Am Chem Soc. 143(31):12294-12303. PMCID: PMC8363578.

108. Wang J, Maschietto F, Guberman-Pfeffer MJ, Reiss K, Allen B, Xiong Y, Lolis E, Batista VS. (2021). Computational insights into the membrane fusion mechanism SARS-CoV-2 at the cellular level. Comput Struct Biotechnol J. 2021;19:5019-5028. PMCID: PMC8442599.

107. Amaya C, Cameron CJF, Devarkar SC, Gerstein MB, Xiong Y, Schlieker C. (2021). Nodal modulator is required to sustain endoplasmic reticulum morphology. J. Biol. Chem. 297(2):100937. PMCID: PMC8327139.

106. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, Jesus PDE, O’Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. (2021). Functional landscape of SARS-CoV-2 cellular restriction. Molecular Cell 81 (12), 2656-2668.

105. Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, N Li, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D, Wang Z, Kirchhoff F, Yang H. (2021). Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins, Proc. Natl. Acad. Sci. USA. 118 (15), e2022269118.

104. Zhao M, Su PY, Castro DA, Tripler TN, Hu Y, Cook M, Ko AI, Farhadian SF, Israelow B, Dela Cruz CS, Xiong Y, Sutton RE, Yale IMPACT Research Team. (2021). Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2. PLoS Pathog. 17, e1009683.

103. Hu Y, Knecht K, She Q, Xiong Y. (2021). Multifaceted HIV-1 Vif interactions with Human E3 Ubiquitin Ligase and APOBEC3s. FEBS Journal 288, 3407-3417.

102. Yang Y, Wu Z, Wang L, Zhou K, Xia K, Xiong Q, Liu L, Zhang Z, Chapman ER, Xiong Y, Melia TJ, Karatekin E, Gu H, Lin C. (2021). Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation. Nature Chem. 13, 335-242.

101. Knecht K, Hu Y, Rubene D, Cook M, Ziegler SJ, Jónsson SR, Xiong Y. (2021). Maedi-visna virus Vif protein uses motifs distinct from HIV-1 Vif to bind zinc and cofactor required for A3 degradation. J. Biol. Chem. 296, 100045.

2020

100. Yuan S, Peng L, Park JJ, Hu Y, Devarkar SC, Dong MB, Wu S, Chen S, Lomakin I, Xiong Y. (2020). Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA. Molecular Cell 80, 1–12.

99. Lim C, Berk JM, Blaise A, Bircher J, Koleske AJ, Hochstrasser M, Xiong Y. (2020). Crystal structure of a novel guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi. Proc. Natl. Acad. Sci. USA. 117 (48) 30380-30390.

98. Temple J, Tripler, TN, She Q, Xiong Y. (2020). A snapshot of HIV-1 capsid-host interactions. Current Research in Structural Biology 2, 222–228.

97. Gisriel CJ, Zhou K, Huang HL, Debus RJ, Xiong Y, Brudvig GW. (2020). The cryo-EM structure of apo-Photosystem II from Synechocystis sp. PCC 6803 reveals early steps in photoactivation. Joule 4, 2131–2148.

96. Berk JM, Lim C, Ronau JA, Chaudhuri A, Chen H, Beckmann JF, Loria JP, Xiong Y, Hochstrasser M. (2020). A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi . Nature Communications 11:2343. doi: 10.1038/s41467-020-15985-4.

95. Slater B, Han X, Chen L, Xiong Y. (2020). Structural insight into T cell coinhibition by PD-1H (VISTA). Proc. Natl. Acad. Sci. USA. 117 (3) 1648-165.

94. Geiger T, Lara-Tejero M, Xiong Y, Galán JE. (2020). Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase. eLife 9:e53473 DOI: 10.7554/eLife.53473

93. Stoneham C, Ramirez WP, Singh R, Suarez M, Debraya A, Lim C, Jia X, Xiong Y, Guatelli J. (2020). A conserved acidic cluster motif in SERINC5 confers resistance to antagonism by HIV-1 Nef. J Virol. pii: JVI.01554-19. doi: 10.1128/JVI.01554-19. [Epub ahead of print]

2019

92. Qin Z, Bonifati S, St Gelais C, Li TW, Kim SH, Antonucci JM, Mahboubi B, Yount JS, Xiong Y, Kim B, Wu L. (2019). The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells. J Biol Chem. pii: jbc.RA119.010360. doi: 10.1074/jbc.RA119.010360. [Epub ahead of print]

91. Hu Y, Desimmie BA, Nguyen HC, Ziegler SZ, Cheng TC, Chen J, Wang J, Wang H, Zhang K, Pathak VK & Xiong Y. (2019). Structural basis of antagonization of human APOBEC3F by HIV-1 Vif. Nat. Struct. Mol. Biol. 26, 1176–1183.

90. Ziegler SJ, Yingxia Hu, Swapnil Devarkar & Xiong Y. (2019) APOBEC3A loop 1 is a determinant for ssDNA binding and deamination. Biochemistry 58, 3838-3847.

89. Oellerich T, Schneider C, Thomas D, Knecht K, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT & Cinatl J Jr. (2019). Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Nature Communications 10:3475, DOI: 10.1038/s41467-019-11413-4.

88. Summers BJ, Digianantonio KM, Smaga SS, Huang P, Zhou K, Gerber EE, Wang W& Xiong Y. (2019). Modular HIV-1 Capsid Assemblies for Investigating Diverse Host-Capsid Recognition Mechanisms. Cell Host & Microbe 26, 203-216.

87. Huang P, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH & Xiong Y. (2019). FEZ1 is recruited to a conserved cofactor site on capsid to promote HIV-1 trafficking. Cell Reports 28, 2373-2385. Epub Aug. 14, 2019.

86. Weber E, Buzovetskya O, Heston L, Yu K, Knecht K, El-Guindy A, Miller G, Xiong Y. (2019). A noncanonical basic motif of EBV ZEBRA protein facilitates recognition of methylated DNA, high-affinity DNA-binding and lytic activation. J. Virol. 93:e00724-19. Epub May 8, 2019.

85. Zhang Y, Cheng TC, Surleac MD, Huang G, Lu Q, Mandell JD, Pontarotti P, Petrescu AJ, Xu A*, Xiong Y *, Schatz DG*. (2019). Transposon Molecular Domestication and the Evolution of the RAG Recombinase. Nature 569, 79-84. * Corresponding authors.

84. Smaga SS, Xu C, Summers BJ, Digianantonio KM, Perilla JR, Xiong Y (2019). MxB restricts HIV-1 by targeting the tri-hexamer interface of the viral capsid. Structure 7(8):1234-1245.

83. Liang Z, Liang F, Teng Y, Chen X, Liu J, Longerich S, Rao T, Green AM, Collins NB, Xiong Y, Lan L, Sung P & Kupfer GM (2019). Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination. Cell Reports 26, 564-572. e5.

82. Lu W, Chen S, Yu J, Behrens R, Wiggins J, Sherer N, Liu S, Xiong Y, Xiang S & Wu L (2019). The Polar Region of HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing gp120-gp41 Association. J. Virol. 93, e02128-18. Epub 2019 Jan 16.

2018

81. Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl Jr. J, Keppler OT, Xiong Y (2018). The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. USA. doi:10.1073/pnas.1805593115

80. Wang W., Chen X., Wolin SL, Xiong Y (2018). Structural basis for transfer RNA mimicry by a bacterial Y RNA. Structure 26, 1–10.

79. Oi C, Treado JD, Levine ZA, Lim CS, Knecht KM, Xiong Y, O’Hern CS, Regan LA (2018) Threonine zipper that mediates protein-protein interactions: Structure and prediction. Protein Sci. doi: 10.1002/pro.3505. [Epub ahead of print]

78. Antonucci JM, Kim SH, Gelais ST, Bonifati S, Buzovetsky O, Knecht K, Duchon AA Xiong Y, Musier-Forsyth KM, Wu L (2018). SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4+ T-cells. J. Virol. 92, pii: e00292-18.

77. Singh R, Stoneham C, Lim C, Jia X, Guenaga J, Wyatt R, Wertheim JO, Xiong Y, Guatelli J (2018). Phosphoserine acidic cluster motifs in the cytoplasmic domains of transmembrane proteins bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes. J. Biol. Chem. doi: 10.1074/jbc.RA118.003080.

76. Chen S, Bonifati S, Qin Z, St. Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. (2018). SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways. Proc. Natl. Acad. Sci. USA. doi:10.1073/pnas.1801213115.

75. Gelais CS, Kim SH, Maksimova VV, Buzovetsky O, Knecht K, Shepard C, Kim B, Xiong Y, Wu L. (2018). A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation. J. Virol. 92, pii: e01787-17.

74. Ziegler SJ, Liu C, Landau M, Buzovetsky O, Desimmie BA, Zhao Q, Sasaki T, Burdick RC, Pathak VK, Anderson1 KS, Xiong Y (2017). Insights into DNA substrate selection by APOBEC3G from structural, biochemical and functional studies. PLoS ONE 13(3): e0195048.

2017

73. Rao T, Longerich S, Zhao W, Aihara H, Sung P, Xiong Y (2017). Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage. DNA Repair 64, 53-58.

72. Buzovetsky O, Tang C, Knecht K, Antonucci JM, Wu L, Xiong Y (2017) The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat. Commun. 9:411. DOI: 10.1038/s41467-017-02783-8.

71. Buzovetsky O, Kwon Y, Pham NT, Kim C, Ira G, Sung P, Xiong Y (2017). Role of the Pif1-PCNA Complex in Pol δ–dependent Strand Displacement DNA Synthesis and Break-Induced Replication. Cell Rep. 2, 1707-1714.

70. Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Ma CJ, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P (2017). BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. Nature 550, 360-365.

69. Lu G, Xu Y, Zhang K, Xiong Y, Li H, Cui L, Wang X, Lou J, Zhai Y, Sun F, Zhang X (2017). Crystal structure of E. coli apolipoprotein N-acyl transferase. Nat. Commun. 8. 15948. 10.1038/ncomms15948.

68. Stoneham CA, Singh R, Jia X, Xiong Y, Guatelli J (2017). Endocytic Activity of HIV-1 Vpu: Phosphoserine-dependent Interactions with Clathrin Adaptors. Traffic, 2017 May 14. PMID: 28504462 [Epub ahead of print]

67. Nguyen HC, Wang W, Xiong Y (2017). Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction. Subcell Biochem. 2017. PMID: 2827148267.

66. Structural basis for ligand binding to the ykkC guanidine riboswitch (2017). Reiss C, Xiong Y, Strobel S. Structure 25, 195-202.

2016

65. Chen X, Yang K, Wu C, Chen C, Hu C, Buzovetsky O, Wang Z, Ji X, Xiong Y, Yang H (2016). Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease. Cell Res. 26,1260-1263.

64. Antonucci JM, St Gelais C, de Silva S, Yount JS, Tang C, Ji X, Shepard C, Xiong Y, Kim B, Wu L (2016). SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity. Nat Med. 22,1072-1074.

63. Liang F, Longerich S, Miller AS, Tang C, Buzovetsky O, Xiong Y, Maranon DG, Wiese C, Kupfer GM, Sung P (2016). Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. Cell Rep. 15, 2118-26.

62. Al-Yacoub N, Shaheen R, Awad SM, Kunhi M, Dzimiri N, Nguyen HC, Xiong Y, Al-Buraiki J, Al-Habeeb W, Alkuraya FS & Poizat C (2016). FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy. Genome Biology 17:2.

61. Shamseldin HE, Smith LL, Kentab A, Alkhalidi H, Summers B, Alsedairy H, Xiong Y, Gupta VA, Alkuraya FS (2016). Mutation of the mitochondrial carrier SLC25A42 causes a novel form of mitochondrial myopathy in humans. Hum Genet. 135, 21-30.

60. Mahiti M, Toyoda M, Jia X, Kuang XT, Mwimanzi F, Mwimanzi P, Walker BD, Xiong Y, Brumme ZL, Brockman MA, Ueno T. (2016). Relative resistance of HLA-B to down-regulation by naturally-occurring HIV-1 Nef sequences. mBio 7:e01516-15.

59. Patel N et al., & Alkuraya FS. (2016). Expanding the clinical, allelic, and locus heterogeneity of retinal dystrophies. Genet. Med. 18, 554-62. Epub. Sep 10, 2015.

58. Shan H, Wang Z, Zhang F, Xiong Y, Yin CC & Sun F. (2016). A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules. Protein Cell 7, 46-62. Epub. Dec 17, 2015.

2015

57. Tang C, Ji X, Wu L & Xiong Y (2015). Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of T592. J. Biol. Chem. 290, 26352-26359. Epub Aug 20, 2015. (JBC paper of the week).

56. Jia X, Zhao Q & Xiong Y (2015). HIV Suppression by Host Restriction Factors and Viral Immune Evasion. Curr. Opin. Struct. Biol. 31:106-14.

55. Ji X & Xiong Y (2015). Two Tales (Tails) of SAMHD1 Destruction by Vpx. Cell Host Microbe 17, 425-427.

54. Nguyen H, Yang H, Fribourgh J, Wolfe LS & Xiong Y (2015). Insights into Cullin-RING E3 ubiquitin ligase recruitment: Structure of the VHL–EloBC–Cul2 complex. Structure 23, 1-9. Epub Feb 5, 2015.

53. Alazami AM et al., & Alkuraya FS (2015). Accelerating Novel Candidate Gene Discovery in Neurogenetic Disorders Through Whole-Exome Sequencing of Prescreened Multiplex Consanguineous Familie. Cell Reports 10, 148-61. Epub, Dec 31, 2014.

2014

52. Zhao Q, Xue X, Longerich S, Sung P & Xiong Y (2014). Structural Insights into 5’ Flap DNA Unwinding and Incision by the Human FAN1 Dimer. Nat. Commun. 5:5726 doi:10.1038/ncomms6726.

51. Fribourgh J, Nguyen H, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A & Xiong Y (2014). Structural Insight into HIV-1 Restriction by Myxovirus Resistance Protein 2 (MxB). Cell Host Microbe 16, 627-638. Epub Oct 9, 2014.

50. Longerich S, Li J, Xiong Y, Sung P & Kupfer M (2014). Stress and DNA repair biology of the Fanconi anemia pathway. Blood 124, 2812-2819. Epub Sep 15, 2014.

49. Ji X, Tang C, Zhao Q, Wang W & Xiong Y (2014) Structural basis of Cellular dNTP regulation by SAMHD1. Proc. Natl. Acad. Sci. USA. 111, E4305-E4314. Epub Sep 29, 2014.

48. Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro J, Huang F, Floyd RW, Yang H, Hamilton W, Bewersdorf J, Xiong Y, Calderwood DA & Mothes W (2014). TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J. Cell Sci. 127 3928-42.

47. Shaheen R, Rahbeeni Z, Alhashem A, Faqeih E, Zhao Q, Xiong Y, Almoisheer A, Al-Qattan SM, Almadani HA, Al-Onazi N, Al-Baqawi BS, Saleh MA & Alkuraya FS (2014). Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH. Am. J. Hum. Gen. 94: 898-904

46. Pateli N, El Mouzan MI, Al-Mayouf SM, Adly N, Mohamed JY, Al Mofarreh MA, Ibrahim N, Xiong Y, Zhao Q, Al-Saleem KA & Alkuraya FS (2014). Study of Mendelian forms of Crohn’s disease in Saudi Arabia reveals novel risk loci and alleles. Gut 124, 2812-2819. Epub Aug 21, 2014.

45. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J & Xiong Y (2014). Structural Basis of HIV-1 Vpu-Mediated BST2 Antagonism via Hijacking of the Clathrin Adaptor Protein Complex 1. eLife 3: e02362.

44. Patel N, Khan AO, Masnour A, Mohamed J, Al-Assiri A, Haddad R, Jia X, Xiong Y, Traboulsi E, Fowzan & Alkuraya FS (2014). Mutations in ASPH, Encoding Aspartyl β-Hydroxylase, Cause Facial Dysmorphism, Lens Dislocation, Anterior Segment Abnormalities, Spontaneous Filtering Blebs (FDLAB or Traboulsi Syndrome). Am. J. Hum. Gen. 94: 755-759.

43. Aldahmesh MA, Li Y, Alhashem A, Anazi S, Alkuraya H, Al-Awaji A, Sakati S, Alkharashi A, Alzahrani S, Al Hazzaa SA, Xiong Y, Sun Z & Alkuraya FS (2014). IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome. Hum. Mol. Genet. 23: 3307-3315. Epub Jan 31, 2014.

42. Fribourgh J, Nguyen H, Wolfe L, DeWitt DC, Zhang W, Yu XF, Rhoades E & Xiong Y (2014). CBFβ plays a critical role facilitating the assembly of the Vif-Cul5 E3 ubiquitin ligase. J. Virol. 88, 3309-19. Epub Jan 3, 2014.

41. Zhao Q, Saro D, Sachpatzidis A, Singh RR, Schlingman D, Zheng X, Mack A, Tsai MS, Mochrie S, Regan L, Meetei AR, Sung P & Xiong Y (2014). MHF complex senses branched DNA via binding a pair of crossover DNA duplexes. Nat. Commun. 5:2987-98.

40. Liu C & Xiong Y (2014). Electron Density Sharpening as a General Crystallographic Technique. J. Mol. Biol. 426, 980-993. Epub Nov 21, 2013.

2013

39. Ji X, Wu Y, Yan J, Mehrens J, Yang H, DeLucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J & Xiong Y (2013). Mechanism of Allosteric Activation of SAMHD1 by dGTP. Nat. Struct. Mol. Biol. 20, 1304-1309. Epub 2013 Oct 20.

2012

38. Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P & Xiong Y (2012). Structural Insight into HIV-1 Capsid Recognition by Rhesus TRIM5α. Proc. Natl. Acad. Sci. USA. 109,18372-18377.

37. Jia X, Sing R, Homann S, Yang H, Guatelli J & Xiong Y (2012). Structural Basis of Evasion of Cellular Adaptive Immunity by HIV-1 Nef. Nat. Struct. Mol. Biol. 19, 701-706.

36. Zheng A, Du J, Xiong Y & Yu XF (2012). Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities. Plos One 7 (7): e38771.

35. Kim J, Roberts A, Yuan H, Xiong Y & Anderson KS (2012). Nucleocapsid Protein Annealing of a Primer-Template Enhances (+)-Strand DNA Synthesis and Fidelity by HIV-1 Reverse Transcriptase. J. Mol. Biol. 415, 866-80. Epub 2011 Dec 23.

2011

34. Burton JL, Xiong Y & Solomon MJ (2011). Mechanisms of Pseudosubstrate Inhibition of the Anaphase Promoting Complex by Acm1. EMBO J. 30, 1818-1829.

33. Butler E, Xiong Y, Wang J & Strobel AS (2011). Structural Basis of Cooperative Ligand Binding by the Glycine Riboswitch. Chem. Biol. 18, 293-298.

2010

32. Pan B, Xiong Y & Steitz TA (2010). How CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA. Science 330, 937-940.

31. Yang H, Wang J, Jia X, Zang T, McNatt MW, Pan B, Meng W, Wang H, Bieniasz PD & Xiong Y (2010). Structural Insight into the Mechanisms of Enveloped Viruses Tethering by Tetherin/BST2. Proc. Natl. Acad. Sci. USA. 107, 18428-18432.

30. Zhang W, Du J, Yu K, Wang T, Xiong Y & Yu XF (2010). Association of potent human anti-viral cytidine deaminases with 7SL RNA and viral RNP in HIV-1 Virions. J. Virol. 84, 12903-12913.

29. Wolfe LS, Calabrese MF, Nath A, Blaho DV, Miranker AD & Xiong Y (2010). Protein-induced photophysical changes to the amyloidindicator dye, thioflavin T. Proc. Natl. Acad. Sci. USA. 107, 16863-16868.

28. Wolfe LS, Stanley BJ, Liu C, Eliason WK, & Xiong Y (2010). Dissection of HIV Vif interaction with the human E3 ubiquitin ligase. J. Virol. 84, 7135-7139.

27. Singh TS, Saro D, Ali AM, Zheng X, Du C, Killen MW, Wahengbam K, Pierce AJ, Sachpatzidis A, Xiong Y, Sung P & Meetei AR (2010). MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM. Mol. Cell 37, 879-86.

26. Zhen A, Wang T, Zhao K, Xiong Y & Yu XF (2010). A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity. J. Virol. 80, 1902-1911. Epub 2009 Nov 25.

2009

25. Murphy JW, Yuan H, Kong Y, Xiong Y & Lolis EJ (2009). Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family. Proteins 78, 1331-1337.

24. Fang Y, Jayaram H, Shane T, Kolmakova-Partensky L, Wu F, Williams C, Xiong Y & Miller C (2009). Structure of a Prokaryotic Virtual Proton Pump at 3.2 Å Resolution. Nature 460, 1040-1043.

23. Randau L#, Stanley BJ, Kohlway A, Mechta S, Xiong Y# & Soll D# (2009). A cytidine deaminase edits tRNAs in archaeal. Science 324, 657-659. (#: corresponding authors)

2008

22. Stanley BJ, Ehrlich ES, Short L, Yu Y, Xiao Z, Yu XF & Xiong Y (2008). Structural Insight into the HIV Vif SOCS Box and Its Role in Human E3 Ubiquitin Ligase Assembly. J. Virol. 82, 8656-63.

21. Xiong Y (2008). From electron microscopy to X-ray crystallography: molecular replacement case studies. Acta Cryst. D64, 76-82.

2007

20. Lomakin IB*, Xiong Y*# & Steitz TA# (2007). The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell 129, 319-332. (*: equal contributions; #: corresponding authors)

2006

19. Xiong Y & Steitz TA (2006). A story with a good ending: tRNA 3’-end maturation by CCA-adding enzymes. Curr Opin Struct Biol. 16, 12-17.

2005

18. Li W, Kamtekar S, Xiong Y, Grindley ND & Steitz TA (2005). Structure of a synaptic resolvase tetramer covalently linked to two cleaved DNAs. Science 309, 1210-1215.

2004

17. Xiong Y & Steitz TA (2004). Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature 430, 640-645.

2003

16. Xiong Y, Li F, Wang J, Weiner AM & Steitz TA (2003). Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide Complexes. Molecular Cell 12, 1165-1172.

15. Pan B, Xiong Y, Shi K & Sundaralingam M (2003). Crystal structure of a bulged RNA tetraplex at 1.1 Å resolution: Implications for a novel binding site in RNA tetraplexe. Structure 11, 1423-1430.

14. Pan B, Xiong Y, Shi K, Deng J & Sundaralingam M (2003). Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: Implications for specific binding in RNA tetraplexes. Structure 11, 815-823.

13. Pan B, Xiong Y, Shi K & Sundaralingam M (2003). An eight-stranded helical fragment in RNA crystal structure: Implications for tetraplex interaction. Structure 11, 825-831.

12. Deng J, Xiong Y, Pan B & Sundaralingam M (2003). Structure of an RNA dodecamer containing a fragment from SRP domain IV of E. coli. Acta Cryst. D59, 1004-1011.

11. Main E, Xiong Y, Cocco M, D’andrea L & Regan L (2003). Design of Stable a Helical Arrays from an Idealized TPR Motif. Structure 11, 497-508.

2002

10. Li F, Xiong Y, Wang J, Cho H, Tomita K, Weiner AM & Steitz TA (2002). Crystal structures of Bacillus Stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Cell 111, 814-824.

9. Smansy SM, Xiong Y, Hemann C, Hille R, Sundaralingam M& Cowan J (2002). Crystal Structure and Stability Studies of C77S HiPIP: A Serine Ligated [4Fe-4S] Cluster. Biochemistry 41, 1195-1201.

2001

8. Deng J*, Xiong Y* & Sundaralingam M (2001). X-ray analysis of an RNA tetraplex (UGGGGU)4 with divalent Sr2+ ions at subatomic resolution (0.61 Å). Proc. Natl. Acad. Sci. USA. 98,13665-13670. (*: equal contributions)

7. Xiong Y, Deng J, Sudarsanakumar C & Sundaralingam M (2001). Crystal Structure of an RNA Duplex r(gugucgcac) with Uridine Bulges. J. Mol. Biol. 313, 573-82.

6. Deng J, Xiong Y, Sudarsanakumar C, Shi K & Sundaralingam M (2001). Crystal structures of two forms of a 14-mer RNA/DNA chimer duplex with double UU bulges: a novel intramolecular U*(A-U) base triple. RNA 7, 1425-31.

5. Xiong Y & Sundaralingam M (2001). Protein-nucleic acid interaction: major groove recognition determinants. In Encyclopedia of Life Sciences (Macmlllan Reference Ltd, London).

2000

4. Xiong Y & Sundaralingam M (2000). Two Crystal Forms of helix II of the X. Laevis 5S rRNA with a cytosine bulge. RNA 6, 1316-1324.

3. Xiong Y & Sundaralingam M (2000). Crystal structure of a DNA-RNA hybrid duplex with a polypurine RNA r(gaagaagag) and a complementary poly pyrimidine DNA d(CTCTTCTTC). Nucleic Acids Res. 28, 2171-2176.

2. Sudarsanakumar C, Xiong Y & Sundaralingam M (2000). Crystal structure of an adenine bulge in the RNA chain of a DNA-RNA hybrid, d(TTCCTCTTC)-(gaagagagag). J. Mol. Biol. 299, 103-112.

1998

1. Xiong Y & Sundaralingam M (1998). Crystal structure and conformation of a DNA·RNA hybrid duplex with a polypurine RNA strand: d(TTCTTBr5CTTC)-(gaagaagaa). Structure 6, 1493-1501.